A novel bis-indole alkaloid was isolated from the flowers of Rauvolfia Yunnanensis Tsiang. Its structure was elucidated as 10,11'- dimethoxy-11,10'-bis-[N(a)-methyl deacetyldeformyl- 1,2-dihydro alcuammiline(2 beta)] (1) on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as IIRESI-MS and comparison with data from the literature. The bis-indole alkaloid displayed more potent antihypertension activity and much lower hepatotoxicity in vivo than Reserpine.