Construction of the [7–5–5] Tricyclic Core of Daphniphyllum Alkaloids via a Cationic Cascade Reaction

Organic Letters
2022.0

Abstract

The [7-5-5] tricyclic core of daphniphyllum alkaloids, containing contiguous stereogenic centers at C14 and C15 and a tetrasubstituted alkene moiety between C9 and C10, was constructed via a cascade reaction that involved an electrocyclic reaction of a pentadienyl cation and intramolecular interception of the resultant cyclopentenyl cation.

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