A new prenylated indole alkaloid 11, 17-epi-mangrovamide A (1), a new natural occurring product, 1,7-dihydroxy-6-methyl-8-hydroxymethyl-xanthone (2), two known alkaloids, mangrovamide A (3) and mangrovamide G (4), and four known polyketide derivatives (5-8) were isolated and identified from the cold-seep sediment derived fungal strain Talaromyces funiculosus SD-523. Their structures were elucidated by combination of nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), quantum chemical electronic circular dichroism (ECD), and DP4+ probability analysis as well as by comparison of the data with literature reports. All isolated compounds were tested for antibacterial activities.