New potent vinca alkaloids resulting from an unexpected isomerization

Tetrahedron Letters
2012.0

Abstract

Four new vinca alkaloids have been elaborated, using an unexpected isomerization and formation of stable enammoniums in very mild conditions. They are cytotoxic on a sub-micromolar range and inhibit microtubule assembly. © 2012 Elsevier Ltd. All rights reserved.

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