Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

A new series of vinca-alkaloids derivatives containing various alpha,beta-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1 muM, thus comparable with vinblastine. CI - Copyright (c) 2015 Elsevier Ltd. All rights reserved.

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