Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China

Phytochemistry
2018.0

Abstract

Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR ((1)H, (13)C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC(50) values of 32.42-62.90鈥痬uM. Only compound 1 had in vitro cytotoxic activity against Bcap37鈥痗ells, with the IC(50) value of 90.61鈥痬uM. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved.

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