Cyclopeptide alkaloids are macrocyclic compounds, the ring system of which consists of a hydroxystyrylamine moiety, an amino acid and a beta-hydroxy amino acid, and which is substituted with one or two additional units. This review covers scientific literature published since 2006 until today. In the past decade, 39 new cyclopeptide alkaloids have been reported. In addition, absolute or relative configurations of known compounds have been established. New sources of known compounds are listed: Plant families from which cyclopeptide alkaloids have been obtained during the past decade include the Acanthaceae, Malvaceae, Phyllanthaceae and Rubiaceae. Some development concerning total synthesis of cyclopeptide alkaloids are discussed. Finally, a critical overview is given of various biological activities that have been reported, i.e. on the central nervous system (CNS), antimicrobial activity and others.