Asymmetric α‐Hydroxylation of β‐Indanone Esters and β‐Indanone Amides Catalyzed by C‐2′ Substituted Cinchona Alkaloid Derivatives

Advanced Synthesis & Catalysis
2016.0

Abstract

The highly catalytic asymmetric alpha-hydroxylation of b-indanone esters and b-indanone amides using peroxide as the oxidant was realized with a new C-2' substituted Cinchona alkaloid derivatives. The two enantiomers of alpha-hydroxy-beta-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the cor-responding alpha-hydroxy-beta-indanone esters and a-hydroxy- b-indanone amides with up to 99% yield and 98% ee.

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