The kinetic resolution of oxazinones by alcoholysis: access to orthogonally protected β-amino acids

Organic & Biomolecular Chemistry
2021.0

Abstract

The catalytic, alcoholytic kinetic resolution of oxazinones is reported. A novel, stereochemically dense cinchona alkaloid-based catalyst can facilitate the highly enantiodiscriminatory (Sup to 101) ring-opening of oxazinones equipped with electrophilic aryl units to generate orthogonally protected β-amino acids for the first time. © The Royal Society of Chemistry 2021.

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