Myrioneuron alkaloids are a class of fast growing natural products elaborated by plants of the genus Myrioneuron. Three new alkaloids secomyrionamide (1), isomyrionine (2), and 12-oxomyriberine A (3) were isolated from Myrioneuron faberi. 1 and 2 presenting the simplest two members of alkaloids derived from M. faberi, and possessing tricyclic C-15 carbon framework, which might furnish precursors for myrionamide and bring new insight into biosynthesis pathway of myrionamide. Structures of 1-3 were elucidated on basis of NMR and MS spectra. Compounds 2 and 3 were tested for inhibitory activity to the hepatitis C virus (HCV), and showed weak activity. (C) 2016 Elsevier Ltd. All rights reserved.