Torrubiellone E, an Antimalarial N-Hydroxypyridone Alkaloid from the Spider Pathogenic Fungus Torrubiella longissima BCC 2022

Natural Product Communications
2014.0

Abstract

Torrubiellone E (1), a new N-hydroxypyridone alkaloid, was isolated from the spider pathogenic fungus Torrubiella longissima BCC 2022, together with the known compounds, torrubiellones A (2) and B (3), and JBIR-130 (4). Compound 1 exhibited antimalarial activity against Plasmodium falciparum K1 with an IC 50 value of 3.2 μg/mL, while it also showed weak cytotoxic activities.

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