Voacalgines A–E, new indole alkaloids from Voacanga grandifolia

Tetrahedron
2013.0

Abstract

Five new indole alkaloids, voacalgines A E (1-5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C-6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2013.10.097

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