Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids. © 2011 Elsevier Ltd. All rights reserved.

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