In total, three sesquiterpene pyridine alkaloids, including two new compounds and a triterpene, were isolated from the n-hexane extract of the stem barks of Hippocratea excelsa. The structures of these compounds were elucidated by spectroscopic methods. Pristimerin, a naturally occurring triterpenoid, exhibited cytotoxicity against L1210 cells. © 2018 Natural Product Incorporation. All Rights Reserved.