Three new monoterpenoid indole alkaloids (1–3), along with five known alkaloids (4–8), were isolated from the leaves of Melodinus suaveolens. Their structures were determined by extensive spectroscopic method and quantum chemical ECD calculation. All the new compounds were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages. © 2019 Phytochemical Society of Europe