Highly Enantioselective and Practical Cinchona-Derived Phase-Transfer Catalysts for the Synthesis of α-Amino Acids This work was supported by grants from Aminogen Co. (Korea) through the Research Center of New Drug Development of Seoul National University and the Research Institute of Pharmaceutical Sciences in the College of Pharmacy of Seoul National University.

Angewandte Chemie International Edition
2002.0

Abstract

A new class of naphthalene-based dimeric cinchona alkaloids 1 are very efficient and practical phase-transfer catalysts in the alkylation of a glycine derivative. The mild reaction conditions and the high catalytic efficiency (high yields and ee values) could make these alkaloids practical catalysts in the industrial synthetic process for natural and nonnatural chiral α-amino acids.

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Highly Enantioselective and Practical Cinchona-Derived Phase-Transfer Catalysts for the Synthesis of α-Amino Acids This work was supported by grants from Aminogen Co. (Korea) through the Research Center of New Drug Development of Seoul National University and the Research Institute of Pharmaceutical Sciences in the College of Pharmacy of Seoul National University.
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