The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors

ChemBioChem
2004.0

Abstract

A common core. Protein phosphatases, such as the dual-specificity phosphatase VHR and the tyrosine phosphatase PTP1B, are key regulators of innumerable cellular processes, and new classes of phosphatase inhibitors are in demand. The azafulvene-containing core structures of the roseophilin and prodigiosin alkaloids define such a new class.

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