Synthesis of new TNF-α Inhibitors and their biological properties

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

New pavine alkaloid derivatives with various substitutions on their aromatic rings and nitrogen atom were prepared and evaluated for their inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS. Some compounds showed potent inhibitory activities in vitro and protected mice against lethality of septic shock induced by LPS and D-galactosamine.

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