Synthesis and structure–activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

3-Alkyl-2-aryl-2-cyclopenten-1-one oxime derivatives (1) were studied as a novel class of inhibitors of tumor necrosis factor α (TNF-α) with regard to synthesis and in vitro SAR inhibition of TNF-α. The in vitro IC50 values of these compounds in rat and human peripheral blood mononuclear cells were at the sub-micromolar level.

Knowledge Graph

Similar Paper

Synthesis and structure–activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production
Bioorganic & Medicinal Chemistry Letters 2002.0
Carbocyclic Nucleosides as Inhibitors of Human Tumor Necrosis Factor-α Production:  Effects of the Stereoisomers of (3-Hydroxycyclopentyl)adenines
Journal of Medicinal Chemistry 1996.0
Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production
Journal of Medicinal Chemistry 2004.0
Substituted Xanthines, Pteridinediones, and Related Compounds as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α
Journal of Medicinal Chemistry 1996.0
Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide’s as an inhibitor of TNF-α production
Bioorganic & Medicinal Chemistry Letters 2018.0
Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties
Medicinal Chemistry Research 2012.0
The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis of new TNF-α Inhibitors and their biological properties
Bioorganic & Medicinal Chemistry Letters 1996.0
From Imidazoles to Pyrimidines:  New Inhibitors of Cytokine Release
Journal of Medicinal Chemistry 2002.0