A new highly conjugated alkaloid of veratramine type, 22S,25S,5 alpha-veratramine-7(8),12(14)-diene-3 beta,13 beta,23 beta-triol-6-one (1), was isolated from the bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia. Its structure was determined on the basis of spectroscopic evidences. (c) 2007 Ji Zhou Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.