Concavine, an unusual diterpenic alkaloid produced by the fungus Clitocybe concava

Tetrahedron Letters
2005.0

Abstract

A novel alkaloid with an unprecedented ring system consisting of a dodecahydro-7-oxa-9a-aza-benzo[a]azulene ring (1), has been isolated from cultures of Clitocybe concava (Basidiomycetae). Its structure and relative stereochemistry were elucidated on the basis of spectroscopic data. Concavine presents a weak antibacterial activity. © 2005 Elsevier Ltd. All rights reserved.

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