Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine and its analogues

Tetrahedron Letters
2005.0

Abstract

A novel cytotoxic butenolide alkaloid, uncinine, has been synthesized for the first time in 8 steps from propargyl alcohol. The sequence features a mild and efficient tandem carbonylative lactonization of a beta-iodoenone precursor using an inorganic base at 1 atm CO, and an indirect attachment of the pyrrolidinone ring via nucleophilic substitution with methyl gamma-aminobutyrate. (c) 2005 Elsevier Ltd. All rights reserved.

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