Two new Daphniphyllum alkaloids with daphnicyclidin-type skeleton, paxiphyllines A (1) and B (2) were isolated from the twigs and the leaves of Daphniphyllum paxianum. Paxiphylline A (1) has an unprecedented additional carbon from a biogenetic perspective. The structures and relative configurations were elucidated on the basis of spectroscopic data. © 2007 Elsevier Ltd. All rights reserved.