Conolutinine, a hexacyclic indole alkaloid with a novel ring system incorporating a diazaspiro center and fused oxadiazepine–tetrahydrofuran rings

Tetrahedron Letters
2009.0

Abstract

A hexacyclic indole alkaloid possessing an unprecedented ring system incorporating a diazaspiro center and fused oxadiazepine-tetrahydrofuran rings has been isolated from the Malayan Tabernaemontana corymbosa. The structure was established by analysis of the spectroscopic data and a possible biogenetic pathway from a cleavamine-type precursor is presented. © 2008 Elsevier Ltd. All rights reserved.

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