Leucolusine, a tetracyclic alkaloid with a novel ring system incorporating an oxindole moiety and fused piperidine-tetrahydrofuran rings

Tetrahedron Letters
2009.0

Abstract

A tetracyclic ring-opened oxindole alkaloid, possessing an unprecedented ring system incorporating fused piperidine-tetrahydrofuran rings, has been isolated from the Malayan species, Leuconotis griffithii. The structure was established by analysis of the spectroscopic data and a possible biogenetic pathway from an Aspidosperma precursor is presented. © 2008 Elsevier Ltd. All rights reserved.

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