Integerrenine, and a new cyclopeptide alkaloid, containing the unusual amine oxide function, anorldianine 27-N oxide, stigmasterol, beta-sitosterol, lupeol, (+)-catechin, (-)-epicatechin and 4-hydroxy-2-methoxy benzoic acid were isolated from the Ecuadorian medicinal plant Heisteria nitida (Engl.), Olacaceae. The structures were determined by UV, IR, NMR and mass spectroscopic investigations and chemical transformations. The cyclopeptide alkaloids have been isolated and characterized for the first time in the family Olacaceae. (C) 1999 Elsevier Science Ltd. All rights reserved.