Berberis orthobotrys produces the new dimer kalashine (1), together with the previously reported pakistanamine (2) and pakistanine (3). Kalashine is the first aporphine-benzylisoquinoline known to be substituted at C-11. Acid catalyzed rearrangement of pakistanamine (2) in 3N HCl leads to 1-0-methylpakistanine (6) together with small amounts of 1-0-methylkalashine (7) and (+)-armepavine (8). Rearrangement of 2 using methanol containing a little 3N HCl gives about equal amounts of 6 and 1,10-di-O-methylpakistanine (9). © 1980.