Berberis orthobotrys has yielded the new aporphine-benzylisoquinolines 1-O-methylpakistanine (2A), kalashine (3B) which is the first such dimer substituted at C-11, and chitraline (4A). Known alkaloids present are pakistanamine (1), pakistanine (3A), berbamine, oxyacanthine and aromoline. A careful study of the dienonephenol rearrangement of pakistanamine (1) has shown that aryl migration to the less hindered side of the dienone system is the heavily favored, but not the exclusive, process. © 1981, American Chemical Society. All rights reserved.