An investigation of the hypotensive alkaloids of Veratrum album, has resulted in the finding that protoveratrine prepared from this source is a mixture of two alkaloids and in the isolation of a new hypotensive alkaloid, named germitetrine B, from the “amorphous alkaloid” fraction. One of the alkaloids, protoveratrine A, was found to conform to the accepted structure of protoveratrine except that it yielded two instead of one mole of acetic acid on hydrolysis. Protoveratrine B was found to yield protoverine, 2-methylbutyric acid, 2,3-dihydroxy-2-methylbutyric acid and two moles of acetic acid on hydrolysis. Germitetrine B was found to yield germine, 2-methylbutyric acid, 2,3-dihydroxy-2-methylbutyric acid and two moles of acetic acid. © 1953, American Chemical Society. All rights reserved.