A new triester alkaloid, neogermitrine, possessing hypotensive activity of the order of that of germitrine has been isolated from Veratrum viride. This alkaloid, while present as the main active constituent in two batches of root collected during the summer seasons of 1948 and 1949, had not been encountered in a previous batch collected during 1947. Neogermitrine, C36H55O11N, is a diacetate-mono-(levo)-α-methylbutyrate of the alkamine germine. On stepwise degradation with dilute methanol it yielded first the known diester alkaloid germidine and finally germine. The infrared spectra of germine and of the ester alkaloids derived from it have been recorded and found to be useful for identification purposes. © 1952, American Chemical Society. All rights reserved.