Solanum hypomalacophyllum has yielded a new 4-keto steroidal alkaloid believed to be 22,26-epimino-4-oxo-5α-cholestane-3β-23β-diol (3a), and desacetylsolaphyllidine (2a) already reported in Solanum ecuadorense. Previous work on this plant yielded solaphyllidine (1) and solamaladine. © 1984, American Chemical Society. All rights reserved.