First Asymmetric Total Syntheses of (−)-Subincanadines A and B, Skeletally Rearranged Pentacyclic Monoterpenoid Indole Alkaloids in Aspidosperma subincanum

Organic Letters
2006.0

Abstract

[GRAPHICS]We achieved the first asymmetric total syntheses of novel Aspidosperma indole alkaloids, (-)-subincanadines A and B, which involve an intramolecular diastereoselective Pictet-Spengler cyclization and an intramolecular Nozaki-Hiyama-Kishi reaction as key steps in the total syntheses.

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