394. Curare alkaloids. Part VIII. Examination of commercial curare, Chondrodendron tomentosum R and P and Anomospermum grandifolium eichl

Journal of the Chemical Society (Resumed)
1948.0

Abstract

The aim of the present investigation was primarily the determination of the botanical source of dextrotubocurarine chloride on account of the use of the latter as an adjunct in anaesthesia. A bush-rope from northern Peru has now given dextrotubocurarine chloride and four non-quaternary bases of which dextrotomentocurine is new. A commercial curare from southern Peru also prepared from Ch. tomentosum has likewise given dextrotubocurarine chloride and four non-quaternary alkaloids. These results are in conflict with the results obtained in Part VI where Ch. tomentosum from northern Peru gave lævotubocurarine chloride. A botanically undifferentiated species may be involved. Anomospermum grandifolium which has a reputation as a constituent of curare has been examined. It contained a quaternary fraction with a curare-action.

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