Two new alkaloids, sepeerine and ocotine, have been isolated from greenheart bark (Nectandra rodiei R. Schomb). Rodiasine, previously obtained only as its dimethiodide, has also been isolated. Sepeerine is shown to be a de-N-methyloxyacanthine of structure (I; R1=Me, R2=H; R3=H and R4=Me or vice versa).