Facile Total Synthesis of (±)-Adalinine

Synlett
1999.0

Abstract

A useful construction of 6,6-disubstituted 2-piperidones has been developed based on allylation of the cyclic N-acyl-N,O-acetals using a combination of Lewis acid and allyltrimethylsilane, leading to the facile total synthesis of a new ladybird alkaloid adalinine in racemic form.

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