(-)-Tsukushinamine-A (1) and (-)-tsukushinamine-B (2), new cage-type lupin alkaloids from Sophora franchetiana Dunn (Leguminosae), were synthesized by means of intramolecular photocyclization from a common lupin alkaloid (-)-rhombifoline (7), coexisting in the same plant. The other (-)-cytisine-type alkaloids, (-)-N-methylcytisine (9) and (-) -N-ethylcytisine (8), were also transformed into the (-)-tsukushinamine-type alkaloids (4–6) in the same way. © 1984, The Pharmaceutical Society of Japan. All rights reserved.