The Library of Cinchona Alkaloids-1,2,3-triazole Derivatives: Structure and Facile Access by “Click Chemistry”

HETEROCYCLES
2005.0

Abstract

New Cinchona alkaloids-1,2,3-triazole derivatives library was prepared readily and efficiently using Huisgen 1,3-dipolar cycloaddition of 9-azido substituted Cinchona alkaloids and various terminal and disubstituted alkynes (click chemistry). Spectroscopic, X-Ray, and molecular modelling data show that these derivatives maintain the conformation of the parent alkaloids.

Knowledge Graph

Similar Paper

The Library of Cinchona Alkaloids-1,2,3-triazole Derivatives: Structure and Facile Access by “Click Chemistry”
HETEROCYCLES 2005.0
New Members of the Cinchona Alkaloids Family: Assembly of the Triazole Heterocycle at the 6′ Position
Molecules 2021.0
Synthesis of 3′-azido-3′-deoxythymidine (AZT)—Cinchona alkaloid conjugates via click chemistry: Toward novel fluorescent markers and cytostatic agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach
European Journal of Medicinal Chemistry 2010.0
Cu(II)‐Catalysed Azide‐Alkyne Cycloaddition Reaction towards Synthesis of β‐Carboline C1‐Tethered 1,2,3‐Triazole Derivatives
ChemistrySelect 2021.0
Synthesis of novel 2-alkyl triazole-3-alkyl substituted quinoline derivatives and their cytotoxic activity
Bioorganic & Medicinal Chemistry Letters 2013.0
Novel 1,2,3-triazole epicinchonas: Transitioning from organocatalysis to biological activities
Synthetic Communications 2021.0
Synthesis of 10,11-DidehydroCinchona Alkaloids and Key Derivatives
Helvetica Chimica Acta 2000.0
7-Chloroquinolinotriazoles: Synthesis by the azide–alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies
European Journal of Medicinal Chemistry 2014.0
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry
Bioorganic & Medicinal Chemistry 2007.0