Cu(II)‐Catalysed Azide‐Alkyne Cycloaddition Reaction towards Synthesis of β‐Carboline C1‐Tethered 1,2,3‐Triazole Derivatives

ChemistrySelect
2021.0

Abstract

Indole and beta-carboline alkaloids exhibit diverse range of significant pharmacological properties as reflected by their contribution in drug-discovery. We have described the synthesis of hybrid molecules containing beta-carboline C1-linked 1,2,3-triazoles in moderate to good yields. The developed transformation was realized by using Cu(II)-catalysed click-reaction of diverse alkynes with in-situ derived rarely explored beta-carboline tethered aliphatic azides. These molecular hybrids also exhibited excellent fluorescence properties.

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