3'-Demethoxy-3'-hydroxystaurosporine, a Novel Staurosporine Analogue Produced by a Blocked Mutant.

3'-Demethoxy-3'-hydroxystaurosporine, a Novel Staurosporine Analogue Produced by a Blocked Mutant. A Nitro Analogue of Staurosporine and Other Minor Metabolites Produced by a Streptomyces longisporoflavus Strain. 3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus Catalyzing the Last Step in the Biosynthesis of Staurosporine. Further Minor Metabolites of Staurosporine Produced by a Streptomyces longisporofiavus Strain. Further Minor Metabolites of Staurosporine Produced by a Streptomyces longisporofiavus Strain. Production of the Staurosporine Aglycon K-252c with a Blocked Mutant of the Staurosporine Producer Strain Streptomyces longisporoflavus and by Biotransformation of Staurosporine with Streptomyces mediocidicus ATCC 13279. A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) I. Screening, taxonomy, fermentation and biological activity. MLR-52,(4'-dementhylamino-4',5'-dihydroxystaurosporine), a new inhibitor of protein kinase C with immunosuppressive activity. A new staurosporine analog from ActinomycetesStreptomycessp. (172614) A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.