4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.

Knowledge Graph

Similar Paper

4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor
Bioorganic & Medicinal Chemistry Letters 2004.0
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
Bioorganic & Medicinal Chemistry Letters 2004.0
1,2-Dihydro-4-quinazolinamines:  Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo
Journal of Medicinal Chemistry 2003.0
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase
Bioorganic & Medicinal Chemistry Letters 2005.0
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
Bioorganic & Medicinal Chemistry Letters 1995.0
3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
Bioorganic & Medicinal Chemistry Letters 2001.0
2-Iminopiperidine and Other 2-Iminoazaheterocycles as Potent Inhibitors of Human Nitric Oxide Synthase Isoforms
Journal of Medicinal Chemistry 1996.0
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors
Bioorganic & Medicinal Chemistry 2021.0
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights
Bioorganic & Medicinal Chemistry Letters 2011.0
2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase
Journal of Medicinal Chemistry 1998.0