3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

3-Phenyl-3.4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor 5j.

Knowledge Graph

Similar Paper

3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
Bioorganic & Medicinal Chemistry Letters 2001.0
1,2-Dihydro-4-quinazolinamines:  Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo
Journal of Medicinal Chemistry 2003.0
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors
Bioorganic & Medicinal Chemistry Letters 2003.0
Dihydroquinolines as Novel n-NOS Inhibitors
Bioorganic & Medicinal Chemistry Letters 2002.0
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor
Bioorganic & Medicinal Chemistry Letters 2004.0
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
Bioorganic & Medicinal Chemistry Letters 1995.0
Discovery of a series of aminopiperidines as novel iNOS inhibitors
Bioorganic & Medicinal Chemistry Letters 2008.0
Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride:  A Highly Selective Inhibitor of Human Inducible Nitric Oxide Synthase
Journal of Medicinal Chemistry 1998.0
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase
Bioorganic & Medicinal Chemistry Letters 2005.0
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase
Bioorganic & Medicinal Chemistry Letters 2010.0