Imidazo[2′-3′-:6,5]dipyrido[3,2-b:2′,3′-e]-1,4-diazepines: non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

The chemistry and SAR of a new series of imidazo[2',3':6,5]dipyrido[3,2-b:2',3'-e]-1,4-diazepines is described. These compounds show improved affinity for HIV-l RTase and antiviral activity in vitro over nevirapine, which has undergone clinical trials.

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