A dipyrido [2,3-b:3′,2′-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3',2'-f]azepines, analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. These compounds exhibit potency equivalent to nevirapine in the inhibition of wild-type and some mutant RT enzymes.

Knowledge Graph

Similar Paper

A dipyrido [2,3-b:3′,2′-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine
Bioorganic & Medicinal Chemistry Letters 1998.0
Novel Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones
Journal of Medicinal Chemistry 1995.0
Imidazo[2′-3′-:6,5]dipyrido[3,2-b:2′,3′-e]-1,4-diazepines: non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine
Bioorganic & Medicinal Chemistry Letters 1992.0
Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones
Journal of Medicinal Chemistry 1998.0
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones
Journal of Medicinal Chemistry 1991.0
Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 7. 8-Arylethyldipyridodiazepinones as Potent Broad-Spectrum Inhibitors of Wild-Type and Mutant Enzymes
Journal of Medicinal Chemistry 1998.0
The synthesis of a dipyrido[3,2-b:3′,4′-e][1,4]diazepinone: Convenient access to a C-ring isomer of the HIV-1 reverse transcriptase inhibitor nevirapine
Bioorganic & Medicinal Chemistry Letters 1995.0
Novel Non-nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. 4. 2-Substituted Dipyridodiazepinones as Potent Inhibitors of Both Wild-Type and Cysteine-181 HIV-1 Reverse Transcriptase Enzymes
Journal of Medicinal Chemistry 1995.0
Novel Non-nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 5. 4-Substituted and 2,4-Disubstituted Analogs of Nevirapine
Journal of Medicinal Chemistry 1995.0
Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
Bioorganic & Medicinal Chemistry 2011.0