Design, synthesis, and binding affinity of a nonpeptide mimic of somatostatin

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

The tetrasubstituted xylofuranose 4 was synthesised as a potential nonpeptide mimic of somatostatin, based on conformational analysis of the endogenous ligand and molecular modelling studies. It displaced the radioligand [ 1251-Ty&octreotide with an IC50 of 23 PM.

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