Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Based on molecular modelling studies of Sandostatin®, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatirffSandostatin®. These compounds displaced 3-[~z~I]-Tyr'-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with ICs0 values between 10 and 15 pM.

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