Based on molecular modelling studies of Sandostatin®, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatirffSandostatin®. These compounds displaced 3-[~z~I]-Tyr'-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with ICs0 values between 10 and 15 pM.