The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

Chlorosubstituted derivatives of tacrine (l), 1,4-methylenetacrine (2), and their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities are described. The most potent analogues are 6-chlorotacrine (1 b) in AChE and 7-chlorotacrine (lc) in BChE inhibition.

Knowledge Graph

Similar Paper

The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties
Bioorganic & Medicinal Chemistry Letters 1992.0
Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors
Journal of Medicinal Chemistry 2014.0
Acetylcholinesterase inhibition by tacrine analogues
Bioorganic & Medicinal Chemistry Letters 1997.0
Homodimeric Tacrine Congeners as Acetylcholinesterase Inhibitors
Journal of Medicinal Chemistry 2002.0
New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates
European Journal of Medicinal Chemistry 2017.0
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
Bioorganic & Medicinal Chemistry Letters 2010.0
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation
European Journal of Medicinal Chemistry 2017.0
Synthesis, anticholinesterase activity and structure–Activity relationships of m-Aminobenzoic acid derivatives
Bioorganic & Medicinal Chemistry Letters 2003.0
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
Bioorganic & Medicinal Chemistry Letters 2001.0
Acetylcholinesterase inhibition by fused dihydroquinazoline compounds
Bioorganic & Medicinal Chemistry Letters 1996.0