Adenosine-2′-monophosphate derivatives: Structural requirements as substrates for inositol monophosphatase

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

Synthesis of derivatives and carbocyclic analogues of adenosine-2' monophosphate, a substrate for bovine inositol monophosphatase, shows that the purine heterocycle and the 4-hydroxymethyl are not required for binding to the enzyme. In contrast, the cyclic ether oxygen is necessary for efficient phosphate hydrolysis.

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