Carbocyclic phosphonate analogs of 2′,3′-dideoxyadenosine-5′-monophosphate as substrates of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetate

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

Several carbocyclic phosphonate analogs of 2',3'-dideoxyadenosine-S-monophosphate (ddAMP) were pyrophosphorylated by Ecoli 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase in the presence of PRPP. Structure-activity relationships are discussed.

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