Topical antiinflammatory dehydroabietylamine derivatives. IV

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

Four derivatives of dehydroabietylamine were synthesized as potential phospholipase-A2 (PLA2) inhibitors and found to be active as topical antiinflammatory as demonstrated in tbe tetradecanoyl phorbol acetate induced ear edema assay (TPA Ear). An attempt has been made to explain the antiinflammatory activity of these compounds based on their biochemical profiles.

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