The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library The design of a dipeptide library for screening at peptide receptor sites Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants The design and implementation of a generic lipopeptide scanning platform to enable the identification of ‘locally acting’ agonists for the apelin receptor Design and synthesis of peptide-based macrocyclic cyclophilin inhibitors The synthesis of β-peptides containing guanidino groups Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase Investigations of azapeptides as mimetics of Leu-enkephalin